Mesangial Cells Cultured from Pregnant Rats Display Reduced Reactivity to Angiotensin II: the Role of Relaxin, Nitric Oxide and AT2 Receptor | Zendy

Lucimeire Nova Carvalho | Zendy; Priscila Cardoso Cristovam | Zendy; Clévia Santos Passos | Zendy; Mírian Aparecida Boim | Zendy

Open Access

Mesangial Cells Cultured from Pregnant Rats Display Reduced Reactivity to Angiotensin II: the Role of Relaxin, Nitric Oxide and AT2 Receptor

Author(s) -

Lucimeire Nova Carvalho,

Priscila Cardoso Cristovam,

Clévia Santos Passos,

Mírian Aparecida Boim

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343333

Subject(s) - relaxin , endocrinology , medicine , nitric oxide , angiotensin ii , receptor , chemistry , renin–angiotensin system , angiotensin receptor , nitric oxide synthase , intracellular , stimulation , biochemistry , blood pressure

Pregnancy is characterized by vasodilatation and increased glomerular filtration rate (GFR), despite overstimulation of the renin angiotensin system (RAS). The mesangial cells (MCs) influences GFR and when cultured from pregnant rats displays refractoriness to Ang II. We evaluated the role of relaxin (RLX) and its receptor (RXFP1), nitric oxide (NO) and the AT2 receptor in this response.

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