Angiotensin II Induces TSLP via an AT1 Receptor/NF-KappaB Pathway, Promoting Th17 Differentiation | Zendy

Hui Zhao | Zendy; Ming Li | Zendy; Lei Wang | Zendy; Yousu Su | Zendy; Hongcheng Fang | Zendy; Jing Lin | Zendy; Nilesh Mohabeer | Zendy; Dazhu Li | Zendy

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Angiotensin II Induces TSLP via an AT1 Receptor/NF-KappaB Pathway, Promoting Th17 Differentiation

Author(s) -

Hui Zhao,

Ming Li,

Lei Wang,

Yousu Su,

Hongcheng Fang,

Jing Lin,

Nilesh Mohabeer,

Dazhu Li

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343327

Subject(s) - angiotensin ii , angiotensin ii receptor type 1 , microbiology and biotechnology , receptor , chemistry , signal transduction , endocrinology , medicine , cancer research , biology

Adaptive immunity plays a critical role in atherosclerosis and hypertension. T helper 17 (Th17) cells, as a new T-cell lineage, are involved in cardiovascular diseases. Dendritic cells (DCs) are the professional antigen-presenting cells with the pivotal role in orchestrating adaptive immunity. Thymic stromal lymphopoietin (TSLP) can activate DCs and trigger adaptive immune responses. What the role of TSLP in atherosclerosis and hypertension has not been investigated.

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