Decreased Hepatic Phosphatidylinositol-3,4,5-Triphosphate (PIP3) Levels and Impaired Glucose Homeostasis in Type 1 and Type 2 Diabetic Rats | Zendy

Prasenjit Manna | Zendy; Sushil K. Jain | Zendy

Open Access

Decreased Hepatic Phosphatidylinositol-3,4,5-Triphosphate (PIP3) Levels and Impaired Glucose Homeostasis in Type 1 and Type 2 Diabetic Rats

Author(s) -

Prasenjit Manna,

Sushil K. Jain

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343325

Subject(s) - glut2 , medicine , endocrinology , glucose homeostasis , protein kinase b , phosphatidylinositol , phosphorylation , inositol , biology , homeostasis , signal transduction , chemistry , glucose transporter , insulin , biochemistry , insulin resistance , receptor

Phosphatidylinositol-3,4,5-triphosphate (PIP3) and phosphatidylinositol-4,5-biphosphate (PIP2) are two well-known lipid second messengers. Polyphosphoinositides have been implicated in the regulation of the signal transduction pathways involved in glucose metabolism using cell culture studies. However, there are no in vivo studies in the literature investigating the status of PIP3 and PIP2 in any of the tissues of diabetic animals. The liver plays an important role in the regulation of whole body glucose homeostasis. This study investigated whether hepatic PIP3 and/or PIP2 levels are altered in diabetes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research