The Role of Swelling-Activated Chloride Currents (ICL,swell) in the Regulatory Volume Decrease Response of Freshly Dissociated Rat Articular Chondrocytes | Zendy

Arturo Ponce | Zendy; Lidia Jimenez-Peña | Zendy; Carlos Tejeda-Guzmán | Zendy

Open Access

The Role of Swelling-Activated Chloride Currents (I_CL,swell) in the Regulatory Volume Decrease Response of Freshly Dissociated Rat Articular Chondrocytes

Author(s) -

Arturo Ponce,

Lidia Jimenez-Peña,

Carlos Tejeda-Guzmán

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343316

Subject(s) - dids , chemistry , biophysics , osmotic concentration , chloride channel , chondrocyte , tonicity , cotransporter , phloretin , patch clamp , chloride , swell , swelling , biochemistry , membrane , sodium , in vitro , biology , materials science , oceanography , receptor , organic chemistry , geology , composite material

Articular chondrocytes dwell in an environment that is continuously changing its osmolarity as a consequence of mechanical loading, yet their volume regulation capabilities (RVD) are not fully understood. This work aimed to determine the osmotic sensitivity of freshly isolated rat chondrocytes, their RVD capabilities and to study the properties of any anion currents associated.

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