Sgk-1 is a Positive Regulator of Constitutive Albumin Uptake in Renal Proximal Tubule Cells | Zendy

Deanne H. Hryciw | Zendy; Wade A. Kruger | Zendy; Jessica F. Briffa | Zendy; Craig Slattery | Zendy; Adelyn Bolithon | Zendy; Aven Lee | Zendy; Philip Poronnik | Zendy

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Sgk-1 is a Positive Regulator of Constitutive Albumin Uptake in Renal Proximal Tubule Cells

Author(s) -

Deanne H. Hryciw,

Wade A. Kruger,

Jessica F. Briffa,

Craig Slattery,

Adelyn Bolithon,

Aven Lee,

Philip Poronnik

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343313

Subject(s) - protein kinase b , endocytosis , biology , sgk1 , microbiology and biotechnology , chemistry , kinase , signal transduction , biochemistry , receptor

Receptor-mediated endocytosis of albumin by the renal proximal tubule requires a number of proteins including megalin/cubilin, sodium/hydrogen exchanger isoform 3 (NHE3) and ClC-5, as well as the PSD-95/Dlg/Zo-1 (PDZ) scaffold sodium/hydrogen exchanger regulatory factor 2 (NHERF2). Despite members from the AGC kinase family, v-Akt Murine Thymoma Viral Oncogene (Akt or Protein Kinase B) and Serum/Glucocorticoid regulated Kinase 1 (Sgk-1) regulating a number of essential proteins in the albumin handling pathway, their role in uptake is largely unknown.

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