Regulation of Contractile Proteins and Protein Translational Signaling in Disused Muscle | Zendy

Hua Liu | Zendy; Eric R. Blough | Zendy; Ravikumar Arvapalli | Zendy; Yeling Wang | Zendy; Peter J. Reiser | Zendy; Satyanarayana Paturi | Zendy; Anjaiah Katta | Zendy; Robert T. Harris | Zendy; Niraj Nepal | Zendy; Miaozong Wu | Zendy

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Regulation of Contractile Proteins and Protein Translational Signaling in Disused Muscle

Author(s) -

Hua Liu,

Eric R. Blough,

Ravikumar Arvapalli,

Yeling Wang,

Peter J. Reiser,

Satyanarayana Paturi,

Anjaiah Katta,

Robert T. Harris,

Niraj Nepal,

Miaozong Wu

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343310

Subject(s) - myosin , skeletal muscle , pi3k/akt/mtor pathway , protein kinase b , muscle atrophy , medicine , myofibril , endocrinology , signal transduction , phosphorylation , itga7 , myocyte , biology , microbiology and biotechnology , chemistry

Muscle disuse can lead to muscle atrophy and impaired skeletal muscle function. How skeletal muscle modulates protein translational signaling in response to prolonged muscle disuse is not well understood. Using the hindlimb unloading (HU) model of muscle atrophy we examined how hindlimb unweighting affects protein translational signaling, including the activation of Akt/mTOR/p70S6K/S6 signaling and the inhibitory association of 4EBP1 with translation initiation factor eIF4E.

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