Aquaporin-2 Levelsin vitroandin vivoare Regulated by VACM-1, a Cul 5 Gene | Zendy

Isabelle P. Le | Zendy; Sarah K. Schultz | Zendy; Bradley T. Andresen | Zendy; Gary L. Dewey | Zendy; Ping Zhao | Zendy; Laura L. Listenberger | Zendy; Peter M.T. Deen | Zendy; Abby Buchwalter | Zendy; Christopher C. Barney | Zendy; Maria A. Burnatowska-Hledin | Zendy

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Aquaporin-2 Levelsin vitroandin vivoare Regulated by VACM-1, a Cul 5 Gene

Author(s) -

Isabelle P. Le,

Sarah K. Schultz,

Bradley T. Andresen,

Gary L. Dewey,

Ping Zhao,

Laura L. Listenberger,

Peter M.T. Deen,

Abby Buchwalter,

Christopher C. Barney,

Maria A. Burnatowska-Hledin

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343305

Subject(s) - aquaporin 2 , aquaporin 3 , western blot , vasopressin , biology , in vivo , chemistry , microbiology and biotechnology , medicine , aquaporin , endocrinology , gene , water channel , biochemistry , mechanical engineering , engineering , inlet

In the renal collecting duct, vasopressin regulates water permeability by a process that involves stimulation of adenylyl cyclase activity, cAMP production and subsequent translocation of water channel aquaporin-2 (AQP2) into the apical plasma membrane. We have previously shown that in cos 1 cells in vitro, both adenylyl cyclase activity and cAMP production can be regulated by VACM-1, a cul 5 gene that forms complexes involved in protein ubiquitination and subsequent degradation.

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