C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation | Zendy

Hung Hsuchou | Zendy; Abba J. Kastin | Zendy; Pramod Kumar Mishra | Zendy; Weihong Pan | Zendy

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C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation

Author(s) -

Hung Hsuchou,

Abba J. Kastin,

Pramod Kumar Mishra,

Weihong Pan

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343302

Subject(s) - neuroinflammation , permeability (electromagnetism) , inflammation , medicine , chemistry , neuroscience , microbiology and biotechnology , biology , biochemistry , membrane

Acute phase C-reactive protein (CRP), elevated in obesity and inflammation, is a major binding protein for leptin. It is thought that CRP contributes to leptin resistance by preventing leptin from crossing the blood-brain barrier (BBB). Here we determined how CRP interacts with the BBB and whether it deters leptin from reaching CNS targets.

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