A Natural Tetrahydropyrimidine, Ectoine, Ameliorates Ischemia Reperfusion Injury after Intestinal Transplantation in Rats | Zendy

Thomas Pech | Zendy; Ichiro Ohsawa | Zendy; Michael Praktiknjo | Zendy; Marcus Overhaus | Zendy; Sven Wehner | Zendy; Martin von Websky | Zendy; Kareem AbuElmagd | Zendy; Gerhild van EchtenDeckert | Zendy; Joerg C. Kalff | Zendy; Nico Schaefer | Zendy

Open Access

A Natural Tetrahydropyrimidine, Ectoine, Ameliorates Ischemia Reperfusion Injury after Intestinal Transplantation in Rats

Author(s) -

Thomas Pech,

Ichiro Ohsawa,

Michael Praktiknjo,

Marcus Overhaus,

Sven Wehner,

Martin von Websky,

Kareem AbuElmagd,

Gerhild van EchtenDeckert,

Joerg C. Kalff,

Nico Schaefer

Publication year - 2012

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000342792

Subject(s) - reperfusion injury , medicine , transplantation , ischemia , liver transplantation , inflammation , pathology , endocrinology , pharmacology

Ischemia reperfusion (I/R) injury after small bowel transplantation leads to inflammatory reactions and loss of structural integrity with subsequent graft contractile dysfunction in the early postoperative phase. The natural tetrahydropyrimidine ectoine (1-,4-,5-,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid; THP) protects the ileal mucosa and muscularis against effects of I/R injury in an experimental model of isolated graft reperfusion. The effects of THP treatment were evaluated in an established experimental intestinal transplant model.

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