Open AccessActivated CD4+ T Cells Target Mesangial Antigens and Initiate Glomerulonephritis
Author(s) -
Yogesh Scindia,
Dominika Nąckiewicz,
Paromita Dey,
Agnieszka Szymula,
Amandeep Bajwa,
Diane L. Rosin,
W. Kline Bolton,
Mark D. Okusa,
Umesh S. Deshmukh,
Harini Bagavant
Publication year - 2012
Publication title -
nephron experimental nephrology
Language(s) - English
Resource type - Journals
ISSN - 1660-2129
DOI - 10.1159/000342368
Subject(s) - antigen , t cell , glomerulonephritis , mesangial cell , mesangium , glomerular mesangium , b cell , immunology , immune system , chemistry , medicine , kidney , antibody
The role of kidney infiltrating T cells in the pathology of lupus nephritis is unclear. This study was undertaken to investigate whether CD4+ T cell responses to a surrogate mesangial antigen can initiate glomerulonephritis.
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