Relevance of the ACTN4 Gene in African-Americans with Non-Diabetic End-Stage Renal Disease | Zendy

Meredith A. Bostrom | Zendy; Peter S. Perlegas | Zendy; Lingyi Lu | Zendy; Andrew A. Hicks | Zendy; Greg Hawkins | Zendy; Maggie Ng | Zendy; Carl D. Langefeld | Zendy; Barry I. Freedman | Zendy; Donald W. Bowden | Zendy

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Relevance of the ACTN4 Gene in African-Americans with Non-Diabetic End-Stage Renal Disease

Author(s) -

Meredith A. Bostrom,

Peter S. Perlegas,

Lingyi Lu,

Andrew A. Hicks,

Greg Hawkins,

Maggie Ng,

Carl D. Langefeld,

Barry I. Freedman,

Donald W. Bowden

Publication year - 2012

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000342205

Subject(s) - single nucleotide polymorphism , end stage renal disease , odds ratio , medicine , diabetic nephropathy , allele , snp , nephropathy , minor allele frequency , genetics , genotype , gastroenterology , endocrinology , diabetes mellitus , biology , disease , gene

African-Americans (AAs) are predisposed to non-diabetic (non-DM) end-stage renal disease (ESRD), and studies have shown a genetic component to this risk. Rare mutations in ACTN4 (α-actinin-4), an actin-binding protein expressed in podocytes, cause familial focal segmental glomerulosclerosis.

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