Inhibition of Histamine H1 Receptor Activity Modulates Proinflammatory Cytokine Production of Dendritic Cells through c-Rel Activity | Zendy

ChinLai Lee | Zendy; ShihHsien Hsu | Zendy; YuhJyh Jong | Zendy; ChihHsing Hung | Zendy; JauLing Suen | Zendy

Open Access

Inhibition of Histamine H1 Receptor Activity Modulates Proinflammatory Cytokine Production of Dendritic Cells through c-Rel Activity

Author(s) -

ChinLai Lee,

ShihHsien Hsu,

YuhJyh Jong,

ChihHsing Hung,

JauLing Suen

Publication year - 2012

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000341637

Subject(s) - histamine , proinflammatory cytokine , allergic inflammation , cytokine , thymic stromal lymphopoietin , inflammation , immunology , ketotifen , signal transduction , microbiology and biotechnology , chemistry , biology , pharmacology , asthma

Histamine exerts diverse effects on immune regulation through four types of histamine receptors (HRs). Among them, type 1 receptor (H1R) plays an important role in allergic inflammation. Dendritic cells (DCs), which express at least three types of HRs, are professional antigen-presenting cells controlling the development of allergic inflammation. However, the molecular mechanisms involved in H1R-mediated NF-ĸB signaling of DCs remain poorly defined.

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