Effect of Chenodeoxycholic Acid on Fibrosis, Inflammation and Oxidative Stress in Kidney in High-Fructose-Fed Wistar Rats | Zendy

Zhijuan Hu | Zendy; Luping Ren | Zendy; Chao Wang | Zendy; Bing Liu | Zendy; Guangyao Song | Zendy

Open Access

Effect of Chenodeoxycholic Acid on Fibrosis, Inflammation and Oxidative Stress in Kidney in High-Fructose-Fed Wistar Rats

Author(s) -

Zhijuan Hu,

Luping Ren,

Chao Wang,

Bing Liu,

Guangyao Song

Publication year - 2012

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000341485

Subject(s) - endocrinology , medicine , farnesoid x receptor , oxidative stress , kidney , chemistry , creatinine , biochemistry , nuclear receptor , transcription factor , gene

Recent studies indicate farnesoid X receptor (FXR) plays an important role in regulating lipid metabolism in kidney disease. The purpose of the present study is to investigate the effect of chenodeoxycholic acid (CDCA), a FXR agonist, on fibrosis, inflammation and oxidative stress in kidney in rats fed on high fructose.

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