Increase of Fatty Acid Oxidation and VLDL Assembly and Secretion Overexpression of PTEN in Cultured Hepatocytes of Newborn Calf
Author(s) -
Shixin Fu,
Qinghua Deng,
Wengtao Yang,
Hongyan Ding,
Xiaoxu Wang,
Peng Li,
Xinwei Li,
Zhe Wang,
Xiaobing Li,
Guowen Liu
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000341477
Subject(s) - pten , tensin , very low density lipoprotein , endocrinology , fatty acid , medicine , secretion , beta oxidation , fatty acid metabolism , biology , fatty acid synthesis , chemistry , metabolism , cancer research , biochemistry , lipoprotein , pi3k/akt/mtor pathway , cholesterol , apoptosis
Phosphatase and tensin homolog (PTEN) is a potent tumor suppressor gene that also plays a vital role in regulating fatty acid metabolism. Here we attempted to elucidate the role of PTEN in the regulation of fatty acid oxidation and the assembly and secretion of very low density lipoprotein (VLDL) in dairy cow liver.
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