Dual Response of Human Leukemia U937 Cells to Hypertonic Shrinkage: Initial Regulatory Volume Increase (RVI) and Delayed Apoptotic Volume Decrease (AVD) | Zendy

Valentina E. Yurinskaya | Zendy; Alexey Moshkov | Zendy; Anna V. Wibberley | Zendy; Florian Läng | Zendy; Michael A. Model | Zendy; Vereninov Aa | Zendy

Open Access

Dual Response of Human Leukemia U937 Cells to Hypertonic Shrinkage: Initial Regulatory Volume Increase (RVI) and Delayed Apoptotic Volume Decrease (AVD)

Author(s) -

Valentina E. Yurinskaya,

Alexey Moshkov,

Anna V. Wibberley,

Florian Läng,

Michael A. Model,

Vereninov Aa

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000341473

Subject(s) - apoptosis , tonicity , volume (thermodynamics) , leukemia , cancer research , u937 cell , microbiology and biotechnology , chemistry , biology , medicine , immunology , biochemistry , physics , quantum mechanics

Osmotic cell shrinkage is a powerful trigger of suicidal cell death or apoptosis, which is paralleled and enforced by apoptotic volume decrease (AVD). Cells counteract cell shrinkage by volume regulatory increase (RVI). The present study explored the response of human U937 cells to hypertonic solution thus elucidating the relationship between RVI and AVD.

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