Increased Nanog Expression Promotes Tumor Development and Cisplatin Resistance in Human Esophageal Cancer Cells | Zendy

Li Yang | Zendy; Xudong Zhang | Zendy; Mingzhi Zhang | Zendy; Junhui Zhang | Zendy; Yuqiao Sheng | Zendy; Xiangdong Sun | Zendy; Qingjiang Chen | Zendy; Lexin Wang | Zendy

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Increased Nanog Expression Promotes Tumor Development and Cisplatin Resistance in Human Esophageal Cancer Cells

Author(s) -

Li Yang,

Xudong Zhang,

Mingzhi Zhang,

Junhui Zhang,

Yuqiao Sheng,

Xiangdong Sun,

Qingjiang Chen,

Lexin Wang

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000341471

Subject(s) - homeobox protein nanog , rex1 , cisplatin , cancer research , small hairpin rna , embryonic stem cell , nanog homeobox protein , cancer stem cell , biology , cancer cell , esophageal cancer , cell culture , stem cell , cancer , microbiology and biotechnology , sox2 , induced pluripotent stem cell , gene , genetics , chemotherapy , gene knockdown

Nanog plays a key role in stem cell self-renewal and pluripotency differentiation in embryonic stem cells ( ESCs). Recently, some studies reported that abnormal expression of Nanog could be detected in several tumors, indicating that Nanog might be related to tumor development. However, studies on the correlation between Nanog expression and esophageal cancer are sparse.

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