Tumor Necrosis Factor a Stimulates Her-2 Cleavage by Activated Caspase-8 | Zendy

Xiaojun Li | Zendy; Yang Zhao | Zendy; Yunfeng Zhang | Zendy; Ning Du | Zendy; Hong Ren | Zendy

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Tumor Necrosis Factor a Stimulates Her-2 Cleavage by Activated Caspase-8

Author(s) -

Xiaojun Li,

Yang Zhao,

Yunfeng Zhang,

Ning Du,

Hong Ren

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000341466

Subject(s) - tumor necrosis factor alpha , apoptosis , cancer research , western blot , caspase 8 , microbiology and biotechnology , small hairpin rna , transcription factor , transfection , caspase 3 , biology , chemistry , cell culture , programmed cell death , endocrinology , gene knockdown , gene , biochemistry , genetics

Her-2 over-expression has been correlated with a poor prognosis in patients with breast cancer. Now, we explored the effect of TNF-α treatment and/or NFĸB activation on Her-2 expression in MCF-7 breast adenocarcinoma cells.

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