Evidence for Mitoxantrone-induced Block of Inwardly Rectifying K+Channels Expressed in the Osteoclast Precursor RAW 264.7 Cells Differentiated with Lipopolysaccharide | Zendy

Chung-Lin Wang | Zendy; Mei-Ling Tsai | Zendy; ShengNan Wu | Zendy

Open Access

Evidence for Mitoxantrone-induced Block of Inwardly Rectifying K⁺Channels Expressed in the Osteoclast Precursor RAW 264.7 Cells Differentiated with Lipopolysaccharide

Author(s) -

Chung-Lin Wang,

Mei-Ling Tsai,

ShengNan Wu

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000341449

Subject(s) - depolarization , chemistry , hyperpolarization (physics) , membrane potential , biophysics , patch clamp , potassium channel , electrophysiology , pharmacology , biochemistry , medicine , stereochemistry , biology , receptor , nuclear magnetic resonance spectroscopy

Mitoxanthrone (MX) is an anthracenedione antineoplastic agent. Whether this drug and other related compounds have any effects on ion currents in osteoclasts remains largely unclear.

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