Ketamine Inhibits Lipopolysaccharide-Induced Astrocytes Activation by Suppressing TLR4/NF-?B Pathway | Zendy

Yuqing Wu | Zendy; Wei Li | Zendy; Ce Zhou | Zendy; Fuzhao Lu | Zendy; Tianhui Gao | Zendy; Yingchun Liu | Zendy; JunLi Cao | Zendy; Yong-Mei Zhang | Zendy; Yongqing Zhang | Zendy; Chenghua Zhou | Zendy

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Ketamine Inhibits Lipopolysaccharide-Induced Astrocytes Activation by Suppressing TLR4/NF-?B Pathway

Author(s) -

Yuqing Wu,

Wei Li,

Ce Zhou,

Fuzhao Lu,

Tianhui Gao,

Yingchun Liu,

JunLi Cao,

Yong-Mei Zhang,

Yongqing Zhang,

Chenghua Zhou

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000341442

Subject(s) - tlr4 , proinflammatory cytokine , glial fibrillary acidic protein , astrocyte , nf κb , lipopolysaccharide , phosphorylation , chemistry , tumor necrosis factor alpha , iκbα , inflammation , microbiology and biotechnology , biology , signal transduction , endocrinology , immunology , biochemistry , immunohistochemistry , central nervous system

Ketamine has been reported to exert anti-inflammatory effects on astrocytes stimulated by lipopolysaccharide (LPS) in vitro and in vivo. However, the mechanism has not been elicited clearly. The aim of this study was to investigate the effects of ketamine on TLR4 expression and NF-ĸB-p65 phosphorylation, as well as the production of proinflammatory cytokines in LPS challenged astrocytes.

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