Immunochemical Analysis of Mutant CFTR in Lung Explants | Zendy

Andrea van Barneveld | Zendy; Isabell Zander | Zendy; Rebecca Hyde | Zendy; Florian Länger | Zendy; A. Simón | Zendy; Marcus Krüger | Zendy; Manfred Ballmann | Zendy; N. Derichs | Zendy; Burkhard Tümmler | Zendy

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Immunochemical Analysis of Mutant CFTR in Lung Explants

Author(s) -

Andrea van Barneveld,

Isabell Zander,

Rebecca Hyde,

Florian Länger,

A. Simón,

Marcus Krüger,

Manfred Ballmann,

N. Derichs,

Burkhard Tümmler

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000341440

Subject(s) - potentiator , cystic fibrosis , lung , gene isoform , context (archaeology) , lung transplantation , mutant , pathology , bronchoalveolar lavage , medicine , δf508 , cystic fibrosis transmembrane conductance regulator , biology , immunology , biochemistry , gene , paleontology

Knowledge about the abundance and distribution of CFTR protein glycoforms in native lung tissue is scarce. For upcoming studies with correctors and potentiators for CFTR it is important to get more information about mutant CFTR protein biochemistry. Target for novel treatment is the most afflicted organ in cystic fibrosis (CF), the lung.

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