Interleukin-1 Induction of Aggrecanase Gene Expression in Human Articular Chondrocytes is Mediated by Mitogen-Activated Protein Kinases | Zendy

Judith Sylvester | Zendy; Mohammed El Mabrouk | Zendy; Rasheed Ahmad | Zendy; Ataf Chaudry | Zendy; Muhammad Zafarullah | Zendy

Open Access

Interleukin-1 Induction of Aggrecanase Gene Expression in Human Articular Chondrocytes is Mediated by Mitogen-Activated Protein Kinases

Author(s) -

Judith Sylvester,

Mohammed El Mabrouk,

Rasheed Ahmad,

Ataf Chaudry,

Muhammad Zafarullah

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000341438

Subject(s) - aggrecanase , pyrrolidine dithiocarbamate , p38 mitogen activated protein kinases , chemistry , adamts , microbiology and biotechnology , mapk/erk pathway , kinase , phosphorylation , protein kinase a , signal transduction , biology , biochemistry , thrombospondin , nf κb , metalloproteinase , matrix metalloproteinase , medicine , osteoarthritis , alternative medicine , pathology , articular cartilage

We investigated the unknown molecular mechanisms of Interleukin-1 (IL-1β)-induced cartilage aggrecan degeneration by aggrecanase (ADAMTS-A Disintegrin And Metalloproteinase with ThromboSpondin motifs) in human articular chondrocytes, a model mimicking human arthritis.

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