Consequences of Stopping and Restarting Leptin in an Adolescent with Lipodystrophy | Zendy

Fatima Kamran | Zendy; K.I. Rother | Zendy; Elaine Cochran | Zendy; Elika Safar Zadeh | Zendy; Phillip Görden | Zendy; R.J. Brown | Zendy

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Consequences of Stopping and Restarting Leptin in an Adolescent with Lipodystrophy

Author(s) -

Fatima Kamran,

K.I. Rother,

Elaine Cochran,

Elika Safar Zadeh,

Phillip Görden,

R.J. Brown

Publication year - 2012

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000341398

Subject(s) - leptin , medicine , endocrinology , lipodystrophy , insulin resistance , discontinuation , metabolic syndrome , dyslipidemia , hypertriglyceridemia , insulin , adipose tissue , diabetes mellitus , triglyceride , obesity , cholesterol , family medicine , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy

Lipodystrophy encompasses a group of rare disorders characterized by deficiency of adipose tissue resulting in hypoleptinemia, and metabolic abnormalities including insulin resistance, diabetes, dyslipidemia, and nonalcoholic steatohepatitis. Leptin replacement effectively ameliorates these metabolic derangements. We report effects of leptin discontinuation and resumption in a child with acquired generalized lipodystrophy.

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