Detection of Phenotype Modifier Genes Using Two-Locus Linkage Analysis in Complex Disorders Such as Major Psychosis | Zendy

Alexandre Bureau | Zendy; Jordie Croteau | Zendy; Chantal Mérette | Zendy; Alain Fournier | Zendy; MarieChristine Chag | Zendy; MarcAndré Roy | Zendy; Michel Maziade | Zendy

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Detection of Phenotype Modifier Genes Using Two-Locus Linkage Analysis in Complex Disorders Such as Major Psychosis

Author(s) -

Alexandre Bureau,

Jordie Croteau,

Chantal Mérette,

Alain Fournier,

MarieChristine Chag,

MarcAndré Roy,

Michel Maziade

Publication year - 2012

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000341392

Subject(s) - phenotype , psychosis , locus (genetics) , genetics , genetic linkage , gene , biology , linkage (software) , psychology , psychiatry

To increase power to detect modifier loci conferring susceptibility to specific phenotypes such as disease diagnoses which are part of a broader disorder spectrum by jointly modeling a modifier and a broad susceptibility gene and to identify modifier loci conferring specific susceptibility to schizophrenia (SZ) or to bipolar disorder (BP) using the approach.

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