Abstracts

s International Heart Forum Beijing, China, August 9–12, 2012 Guest Editor Shengshou Hu, Beijing, China Basel • Freiburg • Paris • London • New York • New Delhi • Bangkok • Beijing • Tokyo • Kuala Lumpur • Singapore • Sydney D ow nl oa de d by : Q ue en 's U ni ve rs ity 19 8. 14 3. 32 .3 3 1/ 31 /2 01 6 3: 15 :3 7 A M S. Karger Medical and Scientific Publishers Basel • Freiburg • Paris • London • New York • Bangalore • Bangkok • Shanghai • Singapore • Tokyo • Sydney Disclaimer The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center (see ‘General Information’). © Copyright 2012 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland) Printed in China ISBN 978–3–318–02224–7 e-ISBN 978–3–318–02225–4 Fax +41 61 306 12 34 E-Mail karger@karger.ch www.karger.com D ow nl oa de d by : Q ue en 's U ni ve rs ity 19 8. 14 3. 32 .3 3 1/ 31 /2 01 6 3: 15 :3 7 A M Epidemiology and Prevention of CV Disease Study on the smoking status of the elderly population in Beijing Lina Ma Xuanwu Hospital, Capital University of Medical Science, Beijing 1, China Objective To explore the smoking status of the elderly population in Beijing. Methods 1826 elderly people in community were selected to participate in the questionnaire survey. Results The proportion of smokers in rural was significantly higher than in urban(40.2% vs 30.0%), the smoking rate of the illiterate was higher than literate(39.1% vs. 30.7%), the proportion of smokers with event was higher than whose without life event(40.8% vs 31.6%), the proportion of smokers with cerebrovascular disease was higher than whose without cerebrovascular disease(39.3% vs. 33.2%); Logistic regression analysis indicated that the elderly who were male, mateless, had life event, and had cerebrovascular disease were prone to be smokers. Conclusions Smoking control is our long term goal, health education and smoking prohibition in public places should be addressed to reduce the smoking rate. D ow nl oa de d by : Q ue en 's U ni ve rs ity 19 8. 14 3. 32 .3 3 1/ 31 /2 01 6 3: 15 :3 7 A M Short-term effects of fish oil supplementation on heart rate variability in humans: a meta-analysis of randomized controlled trials Wei Xin, Xiaoying Li First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China Background Effects of fish oil on heart rate variability, an index of autonomic function in humans, remain controversial. We performed a meta-analysis to investigate the influence of fish oil on parameters of heart rate variability. Methods Human intervention studies were identified by systematic search of Medline, Embase, Cochrane‘s library and references of related reviews and studies through March 2012. Random-effect model was applied to estimate the pooled results. Prespecified subgroup analyses were performed to explore the influence of study characteristics on the overall outcomes. Results A total of seventeen studies were reviewed. Meta-analysis results showed that standard deviation of normal-to-normal interval (SMD = 0.10, 95% CI -0.11 to 0.30, p = 0.35) and root mean square of successive differences (SMD = 0.05, 95% CI -0.18 to 0.27, p = 0.35), two of the time domain parameters of heart rate variability, were not significantly influenced by fish oil supplementation. For frequency domain parameters, by fish oil supplementation, the high-frequency power, a surrogate of vagal function, was significantly increased (SMD = 0.34, 95% CI 0.10 to 0.58, p = 0.005), the low-frequency power was not significantly affected (SMD = 0.00, 95% CI -0.24 to 0.24, p = 0.99), and the ratio between the low and high-frequency power showed a trend of reduction (SMD = -0.22, 95% CI -0.47 to 0.03, p = 0.08). Subgroup analyses according to predefined study characteristics, such as mean age, gender and healthy status of the participants, total dose and ratio between EPA and DHA, follow-up duration, β-blocker usage and Jadad scores, retrieved no significant results. Conclusions Short-term fish oil supplementation may favorably influence the frequency domain parameters of heart rate variability, indicating enhancement of vagal tone may be an important mechanism underlying the antiarrhythmic effect of fish oil. Large scale clinical trials with adequate statistical power are needed to confirm these effects and their clinical relevance in the future. D ow nl oa de d by : Q ue en 's U ni ve rs ity 19 8. 14 3. 32 .3 3 1/ 31 /2 01 6 3: 15 :3 7 A M Association between rantes -403G/A and CCR5 Delta32 polymorphisms and coronary artery disease: A meta-analysis Yanmei Cheng, Naqiang Lu, Aimin Dang State Key Laboratory of Cardiovascular Disease,Fuwai Hospital, National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China Introduction Regulated on activated normal T-cell expressed and secreted (RANTES/CCL5) is a chemokine. CCR5 is the receptor for CCL5. Recent studies suggested a possible role for CCL5 and CCR5 in atherogenesis and gene encoding RANTES and CCR5 might potentially modulate the atherosclerotic pathogenesis. However studies exploring the association between RANTES -403G/A and CCR5 Delta32 (∆ccr5) polymorphisms and CAD were conflicting. Here we did a meta-analysis to fully evaluate these associations. Methods We systematically searched PUBMED and EMBASE to get related genetic association studies. Odds ratio (OR) with 95% confidence interval (CI) of each study were calculated. Cochran‘s Q test was used to evaluate the between-study heterogeneity. Egger‘s test and Funnel plots were used to assess publication bias. Results Totally seven eligible studies covering 4121 cases and 2042 controls were included in RANTES 403G/A analysis. Seven studies with 4874 cases and 2185 controls were included in CCR5 ∆ccr5 polymorphism analysis. The pooled OR of −403A allele compared to -403G was 1.02 (0.82, 1.26) in dominant model, 1.04 (0.91, 1.18) in additive model, and 1.14 (0.77, 1.67) in recessive model, respectively. However, subgroup analysis of Caucasian indicated an increased risk for CAD with combined ORs 1.22 (1.06, 1.40) and 1.26 (1.10, 1.44) in dominant and additive models, respectively, with a higher risk 1.52 (0.79, 1.59) in recessive model although not reaching statistical significance. The pooled OR of ∆ccr5 allele compared to non-∆ccr5 allele was1.03 (0.89, 1.20) in dominant model,0.77 (0.42, 1.40) in recessive model and 1.02 (0.87, 1.18) in additive model. No publication bias was found except that a slight publication bias in -403G/A recessive model. Conclusions The results showed that -403A might be a potential risk factor for CAD in Caucasian. However, no association was found between CCR5∆ccr5 polymorphisms and CAD. D ow nl oa de d by : Q ue en 's U ni ve rs ity 19 8. 14 3. 32 .3 3 1/ 31 /2 01 6 3: 15 :3 7 A M Relation between serum C-Reactive protein and lipid profiles on the risk of hypertension and prehypertension in Mongolian adults of inner Mongolia, china Shihui Zhang 1 , Hongmin Lu 2 , Tan Xu 1 , Yonghong Zhang 1 1 Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China 2 Department of anesthesiology, Tongliao Municipal Hospital, Inner Mongolia, Tongliao Nei Mongol, China Objective To investigate the relation between C-reactive protein(CRP) and lipid profiles on the risk of hypertension and prehypertension in Mongolian adults of Inner Mongolia. Methods The systolic and diastolic blood pressure, height, weight and waist circumference(WC) were measured and factors such as smoking, alcohol intake, family history of hypertension, etc. were investigated and CRP, low-density lipoprotein cholesterol(LDL-C), triglycerides(TG) were tested for 2589 adults aged ≥20 years who lived in Kezuohou Banner and Naiman Banner in Inner Mongolia. The risk of hypertension and prehypertension according to CRP and LDL-C (TG) were analyzed by univariate and multivariate analysis. Results Among hypertensives, prehypertensives and normotensives, hypertensives had highest levels of CRP, LDL-C and TG while normotensives had the lowest levels of the three indices. According to CRP and LDL-C, when subjects had high levels of CRP and LDL-C, the prevalence of hypertension(prehypertension) was the highest among four subgroups and the adjusted OR of hypertension(prehypertension) was 1.756(1.242,2.484)[ 1.770(1.321,2.372)] , the highest among subgroups, too. Meanwhile, subjects with high level of CRP an