Neuroprotective Effects of Granulocyte Colony-Stimulating Factor on Ischemia-Reperfusion Injury of the Retina
Author(s) -
Chieko Shima,
Yasushi Adachi,
Keizo Minamino,
Mitsuhiko Okigaki,
Ming Shi,
Yuichiro Imai,
Seiji Yanai,
Kanji Takahashi,
Susumu Ikehara
Publication year - 2012
Publication title -
ophthalmic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 54
eISSN - 1423-0259
pISSN - 0030-3747
DOI - 10.1159/000340059
Subject(s) - inner nuclear layer , neuroprotection , tunel assay , retina , outer nuclear layer , inner plexiform layer , ganglion cell layer , terminal deoxynucleotidyl transferase , retinal , reperfusion injury , retinal ganglion cell , ischemia , saline , chemistry , apoptosis , endocrinology , medicine , biology , pathology , ophthalmology , biochemistry , neuroscience
It has been reported that granulocyte colony-stimulating factor (G-CSF) provides neuroprotection in models in which neuronal cell death is induced. This research was designed to investigate the effects of G-CSF on neurodegeneration of the inner retinal layer in a rat model of ischemic reperfusion (I/R) injury.
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