N-Acetylcysteine Downregulation of Lysyl Oxidase Activity Alleviating Bleomycin-Induced Pulmonary Fibrosis in Rats | Zendy

Shifeng Li | Zendy; Xiaoxiao Yang | Zendy; Wande Li | Zendy; Jingjie Li | Zendy; Xingwen Su | Zendy; Lijun Chen | Zendy; Guangmei Yan | Zendy

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N-Acetylcysteine Downregulation of Lysyl Oxidase Activity Alleviating Bleomycin-Induced Pulmonary Fibrosis in Rats

Author(s) -

Shifeng Li,

Xiaoxiao Yang,

Wande Li,

Jingjie Li,

Xingwen Su,

Lijun Chen,

Guangmei Yan

Publication year - 2012

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000340041

Subject(s) - medicine , lysyl oxidase , bleomycin , downregulation and upregulation , pulmonary fibrosis , acetylcysteine , fibrosis , pharmacology , pathology , enzyme , biochemistry , chemotherapy , antioxidant , gene , chemistry

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease without beneficial therapy, except for lung transplantation. A high oral dose of N-acetylcysteine (NAC) added to prednisone and azathioprine has been found to improve lung function in IPF patients, though the mechanism of action remains poorly understood.

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