Gentamicin Pharmacokinetics and Pharmacodynamics during Short-Daily Hemodialysis | Zendy

Brian S. Decker | Zendy; Ahmed Mohamed | Zendy; Mary Chambers | Zendy; Michael A. Kraus | Zendy; Sharon M. Moe | Zendy; Kevin M. Sowinski | Zendy

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Gentamicin Pharmacokinetics and Pharmacodynamics during Short-Daily Hemodialysis

Author(s) -

Brian S. Decker,

Ahmed Mohamed,

Mary Chambers,

Michael A. Kraus,

Sharon M. Moe,

Kevin M. Sowinski

Publication year - 2012

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000339937

Subject(s) - medicine , pharmacokinetics , gentamicin , dosing , nonmem , population , pharmacodynamics , hemodialysis , pharmacology , urology , anesthesia , antibiotics , chemistry , biochemistry , environmental health

Gentamicin pharmacokinetics have not been described in patients undergoing short-daily hemodialysis (SDHD). The aim of this study is to describe gentamicin pharmacokinetics and dialytic clearance (Cl(dial)) in SDHD patients and simulate gentamicin exposure after six dosing regimens to help guide future dosing.

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