Soluble Epoxide Hydrolase Inhibition Exhibits Antihypertensive Actions Independently of Nitric Oxide in Mice with Renovascular Hypertension | Zendy

Libor Kopkan | Zendy; Zuzana Husková | Zendy; Alexandra Sporková | Zendy; Šárka Varcabová | Zendy; Zuzana Honetschlägerová | Zendy; Sung Hee Hwang | Zendy; Hsing-Ju Tsai | Zendy; Bruce D. Hammock | Zendy; John D. Imig | Zendy; Herbert J. Kramer | Zendy; Marcela Bürgelová | Zendy; Alžběta Vojtíšková | Zendy; Petr Kujal | Zendy; Zdeňka Vernerová | Zendy; Luděk Červenka | Zendy

Open Access

Soluble Epoxide Hydrolase Inhibition Exhibits Antihypertensive Actions Independently of Nitric Oxide in Mice with Renovascular Hypertension

Author(s) -

Libor Kopkan,

Zuzana Husková,

Alexandra Sporková,

Šárka Varcabová,

Zuzana Honetschlägerová,

Sung Hee Hwang,

Hsing-Ju Tsai,

Bruce D. Hammock,

John D. Imig,

Herbert J. Kramer,

Marcela Bürgelová,

Alžběta Vojtíšková,

Petr Kujal,

Zdeňka Vernerová,

Luděk Červenka

Publication year - 2012

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000339883

Subject(s) - epoxide hydrolase 2 , chemistry , enos , endocrinology , medicine , renovascular hypertension , kidney , nitric oxide synthase , nitric oxide , blood pressure , metabolite , pharmacology , biochemistry , enzyme

The present study was performed to examine whether the blood pressure (BP)-lowering effects of soluble epoxide hydrolase (sEH) inhibition in two-kidney, one-clip (2K1C) Goldblatt hypertension are nitric oxide (NO) dependent.

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