In vitro and in vivo Protection against Indomethacin-Induced Small Intestinal Injury by Proton Pump Inhibitors, Acid Pump Antagonists, or Indomethacin-Phosphatidylcholine | Zendy

Yun Jeong Lim | Zendy; Tri M. Phan | Zendy; Elizabeth J. Dial | Zendy; David Y. Graham | Zendy; Lenard M. Lichtenberger | Zendy

Open Access

In vitro and in vivo Protection against Indomethacin-Induced Small Intestinal Injury by Proton Pump Inhibitors, Acid Pump Antagonists, or Indomethacin-Phosphatidylcholine

Author(s) -

Yun Jeong Lim,

Tri M. Phan,

Elizabeth J. Dial,

David Y. Graham,

Lenard M. Lichtenberger

Publication year - 2012

Publication title -

digestion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.882

H-Index - 75

eISSN - 1421-9867

pISSN - 0012-2823

DOI - 10.1159/000339882

Subject(s) - lansoprazole , omeprazole , in vivo , pharmacology , proton pump inhibitor , medicine , phosphatidylcholine , chemistry , gastroenterology , biochemistry , biology , phospholipid , membrane , microbiology and biotechnology

Proton pump inhibitors (PPIs) are widely used to prevent nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcers. NSAIDs produce small intestinal injury and some PPIs have been reported to protect against NSAID-induced small bowel injury in rats. The aim of this study was to compare PPIs, revaprazan, and phosphatidylcholine-associated indomethacin (Indo-PC) for protection against indomethacin (Indo)-induced small bowel injury.

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