Cytokine Secretion from Human Monocytes Potentiated by P-Selectin-Mediated Cell Adhesion | Zendy

Junsuke Suzuki | Zendy; Eri Hamada | Zendy; Tomonori Shodai | Zendy; Go Kamoshida | Zendy; Sanae Kudo | Zendy; Saotomo Itoh | Zendy; Junzo Koike | Zendy; Kisaburo Nagata | Zendy; Tatsuro Irimura | Zendy; Tsutomu Tsuji | Zendy

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Cytokine Secretion from Human Monocytes Potentiated by P-Selectin-Mediated Cell Adhesion

Author(s) -

Junsuke Suzuki,

Eri Hamada,

Tomonori Shodai,

Go Kamoshida,

Sanae Kudo,

Saotomo Itoh,

Junzo Koike,

Kisaburo Nagata,

Tatsuro Irimura,

Tsutomu Tsuji

Publication year - 2012

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000339857

Subject(s) - secretion , immunology , cytokine , cell adhesion molecule , monocyte , l selectin , adhesion , microbiology and biotechnology , chemistry , biology , endocrinology , organic chemistry

P-selectin is a carbohydrate-recognizing cell adhesion molecule expressed on activated platelets and endothelial cells. It plays a crucial role in the recruitment of leukocytes to inflammatory and hemorrhagic sites. Cell adhesion mediated by P-selectin induces leukocyte activation, such as the generation of reactive oxygen species and the expression of blood coagulation factors. We assessed how P-selectin-mediated cell adhesion affects cytokine secretion from monocytes.

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