Clinical Implication of Targeting of Cancer Stem Cells | Zendy

Lili Zhao | Zendy; Yuechao Zhao | Zendy; Qiyu Bao | Zendy; Hanno Nieß | Zendy; K. W. Jauch | Zendy; Christiane J. Bruns | Zendy

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Clinical Implication of Targeting of Cancer Stem Cells

Author(s) -

Lili Zhao,

Yuechao Zhao,

Qiyu Bao,

Hanno Nieß,

K. W. Jauch,

Christiane J. Bruns

Publication year - 2012

Publication title -

european surgical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.658

H-Index - 46

eISSN - 1421-9921

pISSN - 0014-312X

DOI - 10.1159/000339610

Subject(s) - cancer stem cell , stem cell , medicine , clinical trial , cancer , cancer research , bioinformatics , biology , pathology , genetics

The existence of cancer stem cells (CSCs) is receiving increasing interest particularly due to its potential ability to enter clinical routine. Rapid advances in the CSC field have provided evidence for the development of more reliable anticancer therapies in the future. CSCs typically only constitute a small fraction of the total tumor burden; however, they harbor self-renewal capacity and appear to be relatively resistant to conventional therapies. Recent therapeutic approaches aim to eliminate or differentiate CSCs or to disrupt the niches in which they reside. Better understanding of the biological characteristics of CSCs as well as improved preclinical and clinical trials targeting CSCs may revolutionize the treatment of many cancers.

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