Heart Rate Reduction by Ivabradine Improves Aortic Compliance in Apolipoprotein E-Deficient Mice | Zendy

Florian Custodis | Zendy; Peter Fries | Zendy; Andreas Müller | Zendy; Christoph Stamm | Zendy; Markus Grube | Zendy; Heyo K. Kroemer | Zendy; Michael Böhm | Zendy; Ulrich Laufs | Zendy

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Heart Rate Reduction by Ivabradine Improves Aortic Compliance in Apolipoprotein E-Deficient Mice

Author(s) -

Florian Custodis,

Peter Fries,

Andreas Müller,

Christoph Stamm,

Markus Grube,

Heyo K. Kroemer,

Michael Böhm,

Ulrich Laufs

Publication year - 2012

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000339547

Subject(s) - apolipoprotein e , ivabradine , medicine , endocrinology , angiotensin ii receptor type 1 , heart rate , angiotensin ii , apolipoprotein b , aorta , cardiology , receptor , chemistry , cholesterol , blood pressure , disease

Impaired vascular compliance is associated with cardiovascular mortality. The effects of heart rate on vascular compliance are unclear. Therefore, we characterized effects of heart rate reduction (HRR) by I(f) current inhibition on aortic compliance and underlying molecular mechanisms in apolipoprotein E-deficient (ApoE(-)/(-)) mice.

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