von Willebrand Factor: More Than a Regulator of Hemostasis and Thrombosis | Zendy

Gui-Ping Luo | Zendy; Bing Ni | Zendy; Yang Xia | Zendy; Yuzhang Wu | Zendy

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von Willebrand Factor: More Than a Regulator of Hemostasis and Thrombosis

Author(s) -

Gui-Ping Luo,

Bing Ni,

Yang Xia,

Yuzhang Wu

Publication year - 2012

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000339426

Subject(s) - von willebrand factor , hemostasis , regulator , platelet , angiogenesis , crosstalk , immunology , pathogenesis , glycoprotein , platelet adhesion , immune system , microbiology and biotechnology , thrombosis , cancer research , biology , medicine , biochemistry , physics , gene , optics

von Willebrand factor (vWF) was first identified as an adhesive glycoprotein involved in hemostasis by Zimmermann in 1971. Since then, vWF has been shown to play a vital role in platelet adhesion, platelet binding to collagen and factor VIII protection. Recent studies have implicated vWF as a regulator of angiogenesis, smooth muscle cell proliferation, tumor cell metastasis and crosstalk in the immune system. In this review, we will discuss the aspects of vWF structure that facilitate its biological effects and speculate on its newly discovered and hypothesized roles in the pathogenesis of several diseases.

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