Beta-Adrenergic Receptors, from Their Discovery and Characterization through Their Manipulation to Beneficial Clinical Application | Zendy

S. Blake Wachter | Zendy; Edward M. Gilbert | Zendy

Open Access

Beta-Adrenergic Receptors, from Their Discovery and Characterization through Their Manipulation to Beneficial Clinical Application

Author(s) -

S. Blake Wachter,

Edward M. Gilbert

Publication year - 2012

Publication title -

cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 63

eISSN - 1421-9751

pISSN - 0008-6312

DOI - 10.1159/000339271

Subject(s) - adrenergic receptor , receptor , transduction (biophysics) , perspective (graphical) , signal transduction , function (biology) , β2 adrenergic receptor , clinical trial , adrenergic , heart failure , medicine , bioinformatics , neuroscience , computational biology , pharmacology , biology , microbiology and biotechnology , computer science , biochemistry , artificial intelligence , agonist

β-Adrenergic receptors (β-AR) are central to the overall regulation of cardiac function. From the first proposed receptor/transmitter concept to the latest clinical β-blocker trials β-AR have been shown to play an important role in cardiac disease and heart failure in particular. This study provides a historical perspective, reviews the latest discoveries and beliefs, and discusses the current clinical practices of β-AR and their modulation with their associated guanine-nucleotide regulatory protein/adenylylcyclasesignal transduction pathways.

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