Downregulation of Fetuin-B and Zinc-a2-glycoprotein is Linked to Impaired Fatty Acid Metabolism in Liver Cells
Author(s) -
Jungwon Choi,
Hao Liu,
Rajib Mukherjee,
Jong Won Yun
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000339065
Subject(s) - lipogenesis , medicine , endocrinology , downregulation and upregulation , fetuin , lipid metabolism , metabolism , glycoprotein , fatty acid metabolism , biology , blood proteins , gene , chemistry , biochemistry
Our recent proteomic study has shown that plasma protein levels of fetuin-B (Ft-B) and zinc-α2-glycoprotein (ZAG) are significantly elevated in obesity-resistant (OR) rats exposed to a high fat diet. Time profiling of the plasma concentrations of Ft-B and ZAG in OR rats has shown stable regulation of these proteins throughout the entire period of rat breeding.
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