cAMP Induces Adhesion of Microvascular Smooth Muscle Cells to Fibronectin via an Epac-Mediated but PKA-independent Mechanism | Zendy

Ali H. Eid | Zendy

Open Access

cAMP Induces Adhesion of Microvascular Smooth Muscle Cells to Fibronectin via an Epac-Mediated but PKA-independent Mechanism

Author(s) -

Ali H. Eid

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000339061

Subject(s) - adhesion , fibronectin , forskolin , microbiology and biotechnology , integrin , cell adhesion , chemistry , vascular smooth muscle , effector , cell adhesion molecule , medicine , endocrinology , biology , in vitro , biochemistry , receptor , smooth muscle , extracellular matrix , organic chemistry

Vascular smooth muscle cells (VSMCs) play important roles, both in physiologic and pathophysiologic processes. Adhesion of these cells is critical for their proper functioning, especially in resistance-sized vessels. Nonetheless, very little is known about mechanisms regulating adhesion of VSMCs. In particular, the role of cAMP and its downstream effectors, PKA and Epac, remain poorly investigated.

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