Suppression of Inflammatory Cytokine Secretion by an NF-?B Inhibitor DHMEQ in Nasal Polyps Fibroblasts | Zendy

Fabiana Cardoso Pereira Valera | Zendy; Kazuo Umezawa | Zendy; María Sol Brassesco | Zendy; Angel Maurício Castro-Gamero | Zendy; R.G.P. Queiroz | Zendy; Carlos Alberto Scrideli | Zendy; Luíz Gonzaga Tone | Zendy; Wilma Terezinha AnselmoLima | Zendy

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Suppression of Inflammatory Cytokine Secretion by an NF-?B Inhibitor DHMEQ in Nasal Polyps Fibroblasts

Author(s) -

Fabiana Cardoso Pereira Valera,

Kazuo Umezawa,

María Sol Brassesco,

Angel Maurício Castro-Gamero,

R.G.P. Queiroz,

Carlos Alberto Scrideli,

Luíz Gonzaga Tone,

Wilma Terezinha AnselmoLima

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000339042

Subject(s) - inflammation , nasal polyps , secretion , tumor necrosis factor alpha , cytokine , immunology , chemokine , fluticasone propionate , nf κb , transcription factor , medicine , cancer research , chemistry , asthma , gene , biochemistry

NF-ĸB is an essential transcription factor strongly associated to inflammatory response in chronic rhinosinusitis with nasal polyps (CRSwNP). DHMEQ is a NF-ĸB inhibitor that has been previously described with a greatpotential indecreasing inflammation in diseases other than CRSwNP. The aim of study isto evaluate the ability of DHMEQ to reducethe inflammatory recruiters on CRSwNP and to compare its anti-inflammatory profile as a single-agent or in association with fluticasone propionate (FP).

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