Myocardial Contractile Dysfunction Induced by Ovariectomy Requires AT1Receptor Activation in Female Rats | Zendy

Rogério Faustino Ribeiro Júnior | Zendy; Brunella M. M. Pavan | Zendy; Felipe Fonseca Potratz | Zendy; Jonaína Fiorim | Zendy; Maylla Ronacher Simões | Zendy; Fernanda Moura Vargas Dias | Zendy; Filipe Lugon Moulin Lima | Zendy; Aurélia Araújo Fernandes | Zendy; Dalton Valentim Vassallo | Zendy; Ivanita Stefa | Zendy

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Myocardial Contractile Dysfunction Induced by Ovariectomy Requires AT₁Receptor Activation in Female Rats

Author(s) -

Rogério Faustino Ribeiro Júnior,

Brunella M. M. Pavan,

Felipe Fonseca Potratz,

Jonaína Fiorim,

Maylla Ronacher Simões,

Fernanda Moura Vargas Dias,

Filipe Lugon Moulin Lima,

Aurélia Araújo Fernandes,

Dalton Valentim Vassallo,

Ivanita Stefa

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000339041

Subject(s) - losartan , medicine , endocrinology , estrogen , p22phox , phospholamban , angiotensin ii , angiotensin ii receptor type 1 , ovariectomized rat , estrogen receptor , receptor , nadph oxidase , heart failure , oxidative stress , cancer , breast cancer

Estrogen deficiency induces myocardial contractile dysfunction and increases cardiovascular disease risk. However, the mechanism underlying this response is unclear. Our aim was to investigate whether AT(1)receptor blockade would prevent ovariectomy-induced myocardial contractile dysfunction.

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