Do Common Variants Separate between Obese Melanocortin-4 Receptor Gene Mutation Carriers and Non-Carriers? The Impact of Cryptic Relatedness | Zendy

Jessica Mühlhaus | Zendy; Carolin Pütter | Zendy; Harald Brumm | Zendy; Harald Grallert | Zendy; Thomas Illig | Zendy; Susann Scherag | Zendy; Thomas Reinehr | Zendy; Wilfried Pott | Zendy; Özgür Albayrak | Zendy; Haijun Wang | Zendy; Anne-Madeleine Bau | Zendy; Susanna Wiegand | Zendy; Annette Grüters | Zendy; Heiko Krude | Zendy; Johannes Hebebrand | Zendy; Anke Hinney | Zendy; Heike Biebermann | Zendy; André Scherag | Zendy

Open Access

Do Common Variants Separate between Obese Melanocortin-4 Receptor Gene Mutation Carriers and Non-Carriers? The Impact of Cryptic Relatedness

Author(s) -

Jessica Mühlhaus,

Carolin Pütter,

Harald Brumm,

Harald Grallert,

Thomas Illig,

Susann Scherag,

Thomas Reinehr,

Wilfried Pott,

Özgür Albayrak,

Haijun Wang,

Anne-Madeleine Bau,

Susanna Wiegand,

Annette Grüters,

Heiko Krude,

Johannes Hebebrand,

Anke Hinney,

Heike Biebermann,

André Scherag

Publication year - 2012

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000338999

Subject(s) - haplotype , single nucleotide polymorphism , genetics , melanocortin 4 receptor , mutation , biology , genotype , gene , melanocortin , receptor

Genome-wide association studies revealed associations of single nucleotide polymorphisms (SNPs) flanking MC4R with body mass index variability and obesity. We genotyped 28 SNPs, covering MC4R, and searched for haplotypes discriminating between obese mutation carriers and non-carriers.

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