Influence of Polymorphisms in Genes Encoding for Insulin-Like Growth Factor (IGF)-I, Insulin, and IGF-Binding Protein (IGFBP)-3 on IGF-I, IGF-II, and IGFBP-3 Levels in Umbilical Cord Plasma | Zendy

Eva Landmann | Zendy; Barbara Kollerits | Zendy; Joachim Kreuder | Zendy; Werner Blum | Zendy; Florian Kronenberg | Zendy; Silvia Rudloff | Zendy

Open Access

Influence of Polymorphisms in Genes Encoding for Insulin-Like Growth Factor (IGF)-I, Insulin, and IGF-Binding Protein (IGFBP)-3 on IGF-I, IGF-II, and IGFBP-3 Levels in Umbilical Cord Plasma

Author(s) -

Eva Landmann,

Barbara Kollerits,

Joachim Kreuder,

Werner Blum,

Florian Kronenberg,

Silvia Rudloff

Publication year - 2012

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000338783

Subject(s) - igfbp3 , insulin like growth factor 2 , biology , insulin like growth factor , endocrinology , allele , insulin like growth factor binding protein , medicine , variable number tandem repeat , locus (genetics) , promoter , minor allele frequency , cord blood , growth factor , gene , genetics , allele frequency , gene expression , receptor

In postnatal life, polymorphisms in the promoter region of IGFBP3 were associated with insulin-like growth factor binding protein (IGFBP)-3 plasma levels. Whether these associations exist in utero has not been studied yet. Polymorphisms in the IGF1 promoter (polymorphic CA-repeat) and the insulin gene variable number tandem repeats locus (INS VNTR) are further polymorphisms of interest, because associations with birth weight have been reported. We aimed to investigate associations between polymorphisms in the promoter regions of IGF1 (wild type 192 bp), IGFBP3 (rs2854744; rs13241830), and INS VNTR (rs689) with cord plasma levels of IGF-I, IGF-II, and IGFBP-3.

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