Well-Differentiated Hand Liposarcoma with Bone Metastases Treated Successfully with Zoledronic Acid: A Molecular Mechanism

events. Cholesterol in the cell membrane is produced from de novo synthesis via hydroxy-methylglutaryl coenzyme A reductase (HMG-CoA reductase) [3]. Zoledronic acid, which is an anti-osteoporotic drug assigned to a class of pharmaceuticals called bisphosphonates, effectively inhibits the enzyme farnesyl diphosphate synthase in the HMG-CoA reductase pathway which can lead to significant reduction in the osteoclast-like cell formation [4, 5]. Therefore, this effect of zoledronic acid might contribute as one of the major mechanisms for reduced bone destruction in WDLS.