Cockroach Allergen per a 7 Down-Regulates Expression of Toll-Like Receptor 9 and IL-12 Release from P815 Cells Through PI3K and MAPK Signaling Pathways | Zendy

Haiwei Yang | Zendy; Xue Kong | Zendy; JiFu Wei | Zendy; Chengcheng Liu | Zendy; Weijuan Song | Zendy; Wei Zhang | Zendy; Wei Wei | Zendy; Shaoheng He | Zendy

Open Access

Cockroach Allergen per a 7 Down-Regulates Expression of Toll-Like Receptor 9 and IL-12 Release from P815 Cells Through PI3K and MAPK Signaling Pathways

Author(s) -

Haiwei Yang,

Xue Kong,

JiFu Wei,

Chengcheng Liu,

Weijuan Song,

Wei Zhang,

Wei Wei,

Shaoheng He

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000338510

Subject(s) - tlr2 , mapk/erk pathway , cytokine , signal transduction , biology , microbiology and biotechnology , mast cell , pi3k/akt/mtor pathway , tlr9 , proinflammatory cytokine , immunology , chemistry , tlr4 , inflammation , gene expression , dna methylation , biochemistry , gene

As a major source of indoor allergens, cockroach causes perennial rhinitis and asthma. Recently, cockroach feces were reported to contain TLR2 agonist, which could directly activate neutrophils to release cytokines. CpG oligodeoxynucleotide (ODN), a Toll-like receptor (TLR)9 activator was also found to induce proinflammatory cytokine release from mast cells. However, influence of specific cockroach allergen on Th1 cytokine release and expression of TLR9 in mast cells remains uninvestigated.

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