Downregulation of Quinone Reductase 2 Attenuates Vascular Smooth Muscle Cells Proliferation and Neointimal Formation in Balloon Injured Rat Carotid Artery | Zendy

Xiwen Zhang | Zendy; Yao Wang | Zendy; Jingbo Cai | Zendy; Xiaofeng Hou | Zendy; Hegui Wang | Zendy; Jiangang Zou | Zendy; Kejiang Cao | Zendy

Open Access

Downregulation of Quinone Reductase 2 Attenuates Vascular Smooth Muscle Cells Proliferation and Neointimal Formation in Balloon Injured Rat Carotid Artery

Author(s) -

Xiwen Zhang,

Yao Wang,

Jingbo Cai,

Xiaofeng Hou,

Hegui Wang,

Jiangang Zou,

Kejiang Cao

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000338499

Subject(s) - vascular smooth muscle , downregulation and upregulation , western blot , balloon catheter , restenosis , blot , cell growth , microbiology and biotechnology , biology , chemistry , medicine , endocrinology , balloon , stent , biochemistry , gene , smooth muscle

Quinone reductase 2 (NQO2) is a flavoprotein that catalyzes the metabolic reduction of quinines, but its biological mechanism in vascular smooth muscle cells (VSMCs) is unclear. The aim of this study was to evaluate the role of NQO2 on VSMCs proliferation and the neointimal formation in balloon injured rat carotid artery.

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