Malignant Pleural Mesothelioma in a Patient with Systemic Sclerosis: The First Report | Zendy

Navneet Singh | Zendy; Karan Madan | Zendy; Anish Bhattacharya | Zendy; Raje Nijhawan | Zendy

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Malignant Pleural Mesothelioma in a Patient with Systemic Sclerosis: The First Report

Author(s) -

Navneet Singh,

Karan Madan,

Anish Bhattacharya,

Raje Nijhawan

Publication year - 2012

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000338375

Subject(s) - medicine , pathology , mesothelioma , radiology , lung cancer , lymph , fluorodeoxyglucose , positron emission tomography , chest pain , lung

Malignant pleural mesothelioma (MPM) is a relatively rare but aggressive pleural tumor. Systemic sclerosis (SSc) is associated with the development of lung cancer and other malignancies. We describe a 58-year-old never-smoker female, previously diagnosed with limited cutaneous SSc, who presented with chest pain on the left side, dyspnea and circumferential nodular left pleural thickening. Fluorodeoxyglucose positron-emission tomography-computed tomography showed intense uptake in the thickened left pleura, mediastinal lymph nodes and left femur. Pleural fluid cytological examination along with nuclear and membranous positivity for Wilms tumor-1 antigen and epithelial membrane antigen on immunocytochemistry confirmed the diagnosis of MPM. To the best of our knowledge, this is the first report of MPM in a patient with SSc.

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