Serum Prolactin Concentrations in Relation to Hypopituitarism and Obesity in Children with Optic Nerve Hypoplasia | Zendy

Amy M. Vedin | Zendy; Pamela GarciaFilion | Zendy; Cassandra Fink | Zendy; Mark Borchert | Zendy; Mitchell E. Geffner | Zendy

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Serum Prolactin Concentrations in Relation to Hypopituitarism and Obesity in Children with Optic Nerve Hypoplasia

Author(s) -

Amy M. Vedin,

Pamela GarciaFilion,

Cassandra Fink,

Mark Borchert,

Mitchell E. Geffner

Publication year - 2012

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000338330

Subject(s) - hypopituitarism , optic nerve hypoplasia , medicine , body mass index , prolactin , endocrinology , growth hormone deficiency , obesity , pediatrics , hypoplasia , hormone , growth hormone

The majority of children with optic nerve hypoplasia (ONH) develop hypopituitarism and many also become obese. These associated conditions are a major cause of morbidity and are possibly due to hypothalamic dysfunction. Because mild hyperprolactinemia often occurs in subjects with disorders of the hypothalamus, we examined whether hyperprolactinemia was present in children with ONH during the first 3 years of life and whether it was a marker for hypopituitarism and/or obesity.

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