Aurora Kinase B Expression in Breast Carcinoma: Cell Kinetic and Genetic Aspects | Zendy

Katalin Hegyi | Zendy; Kristóf Égervári | Zendy; Zsuzsa Sándor | Zendy; Gábor Méhes | Zendy

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Aurora Kinase B Expression in Breast Carcinoma: Cell Kinetic and Genetic Aspects

Author(s) -

Katalin Hegyi,

Kristóf Égervári,

Zsuzsa Sándor,

Gábor Méhes

Publication year - 2012

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000338082

Subject(s) - aurora b kinase , biology , mitosis , cell growth , cancer research , gene , chromosome , microbiology and biotechnology , genetics , kinetochore

Mitotic deregulations may contribute significantly to cell division errors and the development of aggressive tumor cells. The mitotic kinase Aurora B is essential for chromosome segregation. Its gene is located at 17p13 in close proximity to the TP53 gene. Although the frequent alteration of this locus is well known, the information about the AURKB status and protein expression is limited.

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