Altered in vitro Proliferation of Mouse SOD1-G93A Skeletal Muscle Satellite Cells | Zendy

Raquel Manzano | Zendy; Janne M. Toivonen | Zendy; Ana Cristina Calvo | Zendy; Sara Oliván | Zendy; P. Zaragoza | Zendy; C. Rodellar | Zendy; Didier Montarras | Zendy; Rosario Osta | Zendy

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Altered in vitro Proliferation of Mouse SOD1-G93A Skeletal Muscle Satellite Cells

Author(s) -

Raquel Manzano,

Janne M. Toivonen,

Ana Cristina Calvo,

Sara Oliván,

P. Zaragoza,

C. Rodellar,

Didier Montarras,

Rosario Osta

Publication year - 2012

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000338061

Subject(s) - sod1 , amyotrophic lateral sclerosis , denervation , biology , skeletal muscle , atrophy , myocyte , medicine , motor neuron , muscle atrophy , endocrinology , microbiology and biotechnology , neuroscience , disease , spinal cord

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neurodegenerative disease characterized by ascending muscle weakness, atrophy and paralysis. Early muscle abnormalities that precede motor neuron loss in ALS may destabilize neuromuscular junctions, and we have previously demonstrated alterations in myogenic regulatory factor (MRF) expression in vivo and in the activation of myofiber-associated skeletal muscle satellite cells (SMSCs) in the mouse model of ALS (SOD1-G93A).

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