Reassessment of sst3 Somatostatin Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-5 | Zendy

Amelie Lupp | Zendy; Falko Nagel | Zendy; Christian Doll | Zendy; Christoph Röcken | Zendy; Matthias Evert | Zendy; Christian Mawrin | Zendy; Wolfgang Saeger | Zendy; Stefan Schulz | Zendy

Open Access

Reassessment of sst<sub>3</sub> Somatostatin Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-5

Author(s) -

Amelie Lupp,

Falko Nagel,

Christian Doll,

Christoph Röcken,

Matthias Evert,

Christian Mawrin,

Wolfgang Saeger,

Stefan Schulz

Publication year - 2012

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000337659

Subject(s) - somatostatin receptor , receptor , somatostatin , medicine , endocrinology , somatostatin receptor 2 , chemistry , monoclonal antibody , microbiology and biotechnology , antibody , biology , biochemistry , immunology

Among the five somatostatin receptors (sst(1)-sst(5)), the sst(3) receptor displays a distinct pharmacological profile. Like sst(2), the sst(3) receptor efficiently internalizes radiolabeled somatostatin analogs. Unlike sst(2), however, internalized sst(3) receptors are rapidly transferred to lysosomes for degradation. Apart from this, very little is known about the clinical relevance of the sst(3) receptor, which may in part be due to the lack of specific monoclonal sst(3) antibodies.

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