The Effects of 17β-estradiol on Mitochondrial Biogenesis and Function in Breast Cancer Cell Lines are Dependent on the ERα/ERβ Ratio | Zendy

Jorge SastreSerra | Zendy; Mercedes NadalSerrano | Zendy; Daniel Gabriel Pons | Zendy; Adamo Valle | Zendy; Jordi Oliver | Zendy; Pilar Roca | Zendy

Open Access

The Effects of 17β-estradiol on Mitochondrial Biogenesis and Function in Breast Cancer Cell Lines are Dependent on the ERα/ERβ Ratio

Author(s) -

Jorge SastreSerra,

Mercedes NadalSerrano,

Daniel Gabriel Pons,

Adamo Valle,

Jordi Oliver,

Pilar Roca

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000337607

Subject(s) - estrogen receptor , mitochondrion , breast cancer , mitochondrial biogenesis , cancer research , estrogen receptor beta , carcinogenesis , cell culture , estrogen receptor alpha , medicine , cell , chemistry , endocrinology , biology , cancer , microbiology and biotechnology , biochemistry , genetics

17β-estradiol (E2) is a risk factor for the development of breast cancer, and cause tumorigenesis in epithelial breast cells. Moreover, E2 has distinct effects on different tissues that are attributed to the presence of two estrogen receptor isoforms, ERα and ERβ.

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