Expression of TMEM16A and SLC4A4 in Human Pancreatic Islets | Zendy

Felicia A. Hanzu | Zendy; Rosa Gasa | Zendy; Nurdan Bulur | Zendy; Pascale Lybaert | Zendy; Ramón Gomis | Zendy; Willy Malaisse | Zendy; Renaud Beauwens | Zendy; Abdullah Sener | Zendy

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Expression of TMEM16A and SLC4A4 in Human Pancreatic Islets

Author(s) -

Felicia A. Hanzu,

Rosa Gasa,

Nurdan Bulur,

Pascale Lybaert,

Ramón Gomis,

Willy Malaisse,

Renaud Beauwens,

Abdullah Sener

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000337587

Subject(s) - islet , immunostaining , pancreas , pancreatic islets , biology , immunohistochemistry , medicine , endocrinology , cotransporter , insulin , chemistry , immunology , organic chemistry , sodium

Stimulation of insulin release by D-glucose is accompanied by Cl(-) and HCO(3)(-) efflux from pancreatic islet cells. The efflux of these anions may involve volume-regulated anion channels, including possibly TMEM16A, and the Na(+)-HCO(3)(-)-cotransporter SLC4A4. The present study was designed to explore the expression of both TMEM16A and SLC4A4 in human pancreatic islets.

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